Yoshiro Saito Selected Research

Proteins (Proteins, Gene)

5/2022	2021 White Paper on Recent Issues in Bioanalysis: Mass Spec of Proteins, Extracellular Vesicles, CRISPR, Chiral Assays, Oligos; Nanomedicines Bioanalysis; ICH M10 Section 7.1; Non-Liquid & Rare Matrices; Regulatory Inputs (Part 1A - Recommendations on Endogenous Compounds, Small Molecules, Complex Methods, Regulated Mass Spec of Large Molecules, Small Molecule, PoC & Part 1B - Regulatory Agencies' Inputs on Bioanalysis, Biomarkers, Immunogenicity, Gene & Cell Therapy and Vaccine).
5/2022	2021 White Paper on Recent Issues in Bioanalysis: ISR for Biomarkers, Liquid Biopsies, Spectral Cytometry, Inhalation/Oral & Multispecific Biotherapeutics, Accuracy/LLOQ for Flow Cytometry (Part 2 - Recommendations on Biomarkers/CDx Assays Development & Validation, Cytometry Validation & Innovation, Biotherapeutics PK LBA Regulated Bioanalysis, Critical Reagents & Positive Controls Generation).
1/2022	Nephronectin influences EAE development by regulating the Th17/Treg balance via reactive oxygen species.
2/2020	Selenoprotein P as a significant regulator of pancreatic β cell function.
1/2018	Pleckstrin homology domain of p210 BCR-ABL interacts with cardiolipin to regulate its mitochondrial translocation and subsequent mitophagy.
1/2018	Selenoprotein P Promotes the Development of Pulmonary Arterial Hypertension: Possible Novel Therapeutic Target.
1/2018	6-Hydroxydopamine induces secretion of PARK7/DJ-1 via autophagy-based unconventional secretory pathway.
1/2017	Eicosapentaenoic acid down-regulates expression of the selenoprotein P gene by inhibiting SREBP-1c protein independently of the AMP-activated protein kinase pathway in H4IIEC3 hepatocytes.
12/2015	The protective role of DJ-1 in ultraviolet-induced damage of human skin: DJ-1 levels in the stratum corneum as an indicator of antioxidative defense.
7/2015	24(S)-Hydroxycholesterol induces RIPK1-dependent but MLKL-independent cell death in the absence of caspase-8.

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Yoshiro Saito Research Topics

Disease

45	Neoplasms (Cancer) 01/2022 - 01/2002
19	Stevens-Johnson Syndrome (Lyell's Syndrome) 01/2021 - 11/2008
14	Drug-Related Side Effects and Adverse Reactions 04/2022 - 04/2005
14	Parkinson Disease (Parkinson's Disease) 03/2018 - 03/2007
11	Neutropenia 01/2014 - 01/2007
9	Type 2 Diabetes Mellitus (MODY) 01/2022 - 11/2010
9	Insulin Resistance 02/2020 - 11/2010
8	Chemical and Drug Induced Liver Injury 10/2022 - 01/2012
8	Necrosis 01/2020 - 06/2006
7	Neuroblastoma 10/2018 - 02/2004
6	Hypersensitivity (Allergy) 12/2019 - 04/2002
6	Pancreatic Neoplasms (Pancreatic Cancer) 01/2016 - 11/2004
5	Interstitial Lung Diseases (Interstitial Lung Disease) 12/2020 - 08/2010
5	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2017 - 12/2008
5	Alzheimer Disease (Alzheimer's Disease) 01/2015 - 02/2009
4	Cicatrix (Scar) 01/2021 - 06/2013
4	Infections 01/2020 - 04/2012
4	Lymphoma (Lymphomas) 07/2015 - 11/2002
3	Pulmonary Arterial Hypertension 12/2019 - 01/2018
3	Fibrosis (Cirrhosis) 01/2019 - 08/2015
3	Muscular Diseases (Myopathy) 12/2016 - 06/2009
3	Atherosclerosis 01/2016 - 12/2005
3	Stomach Neoplasms (Stomach Cancer) 10/2015 - 01/2012
3	Diarrhea 01/2014 - 01/2003
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2011 - 08/2006
2	Confusion (Bewilderment) 05/2022 - 05/2022
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 05/2022 - 08/2021
2	Rheumatoid Arthritis 05/2022 - 08/2021
2	Obesity 01/2022 - 05/2014
2	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 08/2021 - 01/2018
2	Prostatic Hyperplasia (Benign Prostatic Hyperplasia) 01/2021 - 01/2018
2	Pulmonary Hypertension 12/2019 - 01/2018
2	Exanthema (Rash) 12/2019 - 08/2014
2	Hyperglycemia 03/2019 - 11/2018
2	Glucose Intolerance 03/2019 - 11/2018
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2018 - 04/2017
2	Hypoxia (Hypoxemia) 01/2018 - 06/2008
2	Rhabdomyolysis 12/2017 - 01/2011
2	Breast Neoplasms (Breast Cancer) 01/2017 - 01/2012
2	Inflammation (Inflammations) 01/2017 - 05/2005
2	Dementia (Dementias) 07/2014 - 03/2013
2	Epilepsy (Aura) 12/2013 - 02/2010

Drug/Important Bio-Agent (IBA)

41	Pharmaceutical PreparationsIBA 04/2022 - 01/2002
22	Biomarkers (Surrogate Marker)IBA 05/2022 - 02/2009
19	Irinotecan (Camptosar)FDA LinkGeneric 01/2014 - 01/2002
18	Proteins (Proteins, Gene)FDA Link 05/2022 - 04/2002
17	Selenoprotein PIBA 01/2022 - 11/2002
12	LipidsIBA 08/2020 - 06/2008
12	Gemcitabine FDA Link 01/2016 - 11/2004
11	HLA-B Antigens (HLA-B)IBA 01/2021 - 11/2008
7	Carbamazepine (Tegretol)FDA LinkGeneric 01/2021 - 02/2010
6	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 11/2010
6	Paclitaxel (Taxol)FDA LinkGeneric 10/2011 - 08/2006
5	Anticonvulsants (Antiepileptic Drugs)IBA 01/2018 - 01/2011
5	Oxidopamine (6 Hydroxydopamine)IBA 01/2018 - 03/2007
5	EnzymesIBA 10/2017 - 04/2002
5	Fluorouracil (Carac)FDA LinkGeneric 01/2012 - 11/2005
4	Allopurinol (Remid)FDA LinkGeneric 01/2021 - 11/2008
4	Phenytoin (Dilantin)FDA LinkGeneric 01/2021 - 11/2013
4	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2018 - 01/2007
4	Glucuronosyltransferase (UDP Glucuronosyltransferase)IBA 02/2011 - 01/2002
3	SeleniumIBA 01/2022 - 01/2013
3	Insulin (Novolin)FDA Link 02/2020 - 01/2017
3	AntipyreticsIBA 01/2020 - 01/2011
3	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 01/2019 - 07/2010
3	Phosphotransferases (Kinase)IBA 10/2018 - 07/2015
3	Protein Deglycase DJ-1IBA 03/2018 - 04/2014
3	NeurotoxinsIBA 01/2018 - 03/2007
3	AntibodiesIBA 01/2017 - 05/2014
3	AntigensIBA 01/2016 - 01/2012
3	Cysteine (L-Cysteine)FDA Link 07/2014 - 10/2010
3	AntioxidantsIBA 11/2012 - 04/2005
3	Cisplatin (Platino)FDA LinkGeneric 05/2010 - 04/2005
3	Cytidine DeaminaseIBA 01/2009 - 04/2005
3	PlatinumIBA 01/2009 - 01/2007
2	Glutathione Transferase (Glutathione S-Transferase)IBA 10/2022 - 01/2011
2	Indicators and Reagents (Reagents)IBA 05/2022 - 05/2022
2	Immunosuppressive Agents (Immunosuppressants)IBA 08/2021 - 01/2019
2	Adrenal Cortex Hormones (Corticosteroids)IBA 02/2021 - 01/2019
2	insulin receptor-related receptor (IRR)IBA 01/2021 - 01/2018
2	HLA-DRB1*04 antigenIBA 12/2020 - 12/2016
2	Anti-Bacterial Agents (Antibiotics)IBA 01/2020 - 01/2011
2	Analgesics (Analgesic Drugs)IBA 01/2020 - 01/2018
2	Ether (Diethyl Ether)IBA 10/2019 - 01/2016
2	Prostaglandin D2IBA 10/2019 - 01/2019
2	Chemotactic FactorsIBA 03/2019 - 05/2014
2	Denosumab FDA Link 02/2019 - 01/2017
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2019 - 10/2015
2	Glutathione (Reduced Glutathione)IBA 01/2018 - 01/2018
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2017 - 09/2014
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 12/2016 - 01/2010
2	HLA Antigens (Human Leukocyte Antigens)IBA 01/2016 - 02/2010
2	Protein Kinases (Protein Kinase)IBA 07/2015 - 05/2014
2	Caspase 8 (Caspase-8)IBA 07/2015 - 04/2014
2	Metformin (Glucophage)FDA LinkGeneric 06/2015 - 01/2014
2	HLA-A31 antigenIBA 01/2015 - 06/2013
2	Amyloid (Amyloid Fibrils)IBA 04/2014 - 05/2013

Therapy/Procedure

13	Therapeutics 12/2019 - 03/2005
7	Drug Therapy (Chemotherapy) 10/2015 - 04/2005
2	Combination Drug Therapy (Combination Chemotherapy) 12/2013 - 07/2007